This Japan-only sequel was released in 2001 for the Neo Geo Pocket Color after Capcom vs. SNK 2. In addition to the 240 characters and 60 action cards from the first part of the game, 124 new cards are added, adding a cast from Garou: Mark of the Wolves, Samurai Shodown: Warriors Rage, The King of Fighters '99 and 2000 for SNK, and Project Justice, Mega Man Legends, Dino Crisis and Onimusha for Capcom, as well as 40 similar reaction cards that can be used during an enemy attack. Another new feature is the special character cards with alternate versions of various characters depicted with regular artwork instead of a super deformed style. Instead of being released in two versions (by SNK and Capcom), this game was released as a single version, which allows players to choose to start with a SNK deck or a Capcom deck. This was the last game to be released for the Neo Geo Pocket Color in Japan.
In 2008, an English translation of the game called Card Fighters' Clash 2 (CFC2) was released as a fan-translated patch to the original game file. This project aims to bring the second card fighters clash game to a wide audience.